Intracellular Calcium Concentration in Nociceptive Effects of Anandamide and Noxious Heat on
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Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats.
As an endogenous agonist at the cannabinoid receptor CB1 and the capsaicin-receptor TRPV1, anandamide may exert both anti- and pronociceptive actions. Therefore we studied the effects of anandamide and other activators of both receptors on changes in free cytosolic calcium ([Ca(2+)](i)) in acutely dissociated small dorsal root ganglion neurons (diameter: < or =30 microm). Anandamide (10 microM)...
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